Sehlopha sa corticobasal syndrome se thehiloeng ho biomarker 

---

Corticobasal syndrome (CBS) ke lefu le hlalosoang ka bongaka le nang le mathata a ho sisinyeha a tsoelang pele le matšoao a cortical, a ka bakoang ke mefuta e fapaneng ea mafu a hlalositsoeng ke neuropathologically. CBS e atisa ho amahanngoa le 4-repeat tauopathies (4RTs), ho kenyeletsoa progressive supranuclear palsy (PSP) le corticobasal degeneration, kapa mixed 3-repeat / 4-repeat tauopathy Alzheimer's disease (AD). Leha ho le joalo, Lewy-type α-synucleinopathies (LTS), TDP-43 proteinopathies, kapa mixed pathologies le tsona li ka hlaha e le CBS. Leha ho le joalo, bohlokoa ba kliniki ba mafu a fapaneng a CBS bo ntse bo sa utloisisoe hantle. Ka hona, phuputso ea hajoale e ikemiselitse ho arola bakuli ba CBS ka limolek'hule ka ho sebelisa li-biomarker bakeng sa amyloid (Aβ), Tau, le α-synuclein (αSyn), e lumellang ho aroloa ha in vivo. 

Re entse phuputso ea sehlopha se ka bang teng se kenyeletsang bakuli ba 50 ba CBS ba ileng ba hlahlojoa ka bongaka Sepetleleng sa Univesithi ea LMU Munich. Litlhahlobo tsa biomarker li ne li kenyelletsa litekanyo tsa mokelikeli oa mokokotlo (CSF) oa likarolelano tsa Aβ42 le Aβ42/40, liteko tsa ho eketsa peo ea [18F]Flutemetamol β-amyloid-PET, [18F]PI-2620 Tau-PET, le liteko tsa ho eketsa peo ea CSF αSyn. Ketane ea leseli la Neurofilament (NfL) ho CSF ​​e sebelitse e le letšoao le sa tobang la ho senyeha ha methapo ea kutlo. Positive kapa negativity ea biomarker e lumelletse karohano ea CBS ka lihlopha tse tšeletseng, e khethollang mekhatlo ea lefu la 'nete e thehiloeng ho motsoako oa Aβ, Tau, le αSyn.  

Liphuputso tsa rona li senotse ho ata ho hoholo ha Tau positivity, moo 90% ea bakuli ba CBS ba nang le Tau-positive, ha Aβ le αSyn positivity li bonoe maemong a 28% le 24%, ka ho latellana. Ho aroloa ha lihlopha tsa lefu tse hlalositsoeng ke biomarker ho bontšitse hore 52% ea linyeoe tsa CBS li ne li tsamaellana le 4RT, 18% le AD, 10% le ho hlaha ha AD le LTS hammoho, 10% le 4RT le LTS, le 4% le LTS e arohaneng. 6% e ile ea lula e sa aroloa. αSyn-positivity e ne e atile haholo maemong a CBS a nang le AD e nahanoang (36%), ha e bapisoa le a nang le 4RT e nahanoang (16%). Ka bongaka, Aβ-positivity e ne e amahanngoa le ho senyeha ho matla ha tsebo ho Tlhahlobo ea Cognitive ea Montreal le Teko ea Dementia Apraxia. Tau positivity e ne e amahanngoa le matšoao a matla a ho sisinyeha empa ha ea ka ea bontša phello e kholo sekhahla sa tsoelo-pele ea lefu. Ka lehlakoreng le leng, bakuli ba nang le αSyn positive ba ile ba hlaha ba e-na le matšoao a bobebe a ho sisinyeha ha mesifa, lintlha tse tlase tsa sekala sa PSP, le tsoelo-pele e liehang ha nako e ntse e ea, e tsamaeang le maemo a tlase haholo a CSF NfL a motheo. 

Phuputso ea rona e totobatsa ho se tšoane ha limolek'hule tsa CBS, e totobatsa bokhoni ba ho arola ka mokhoa oa biomarker ho ntlafatsa ho nepahala ha tlhahlobo le ho tataisa mekhoa ea phekolo e reretsoeng. 

Bala pampiri